Ubiquitin Antibody

• Background:

  This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  7314

• Swiss Prot:

  P0CG47

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human Ubiquitin (NP_061828.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Neuroscience

• Purification:

  Affinity purification

• Positive Control:

  BT-474

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 17-110kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  UBB

• Positive Control 2:

  SW480

• Positive Control 3:

  Mouse kidney

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Rat brain

• Positive Control 6:

  Rat kidney

• NCBI Official Name:

  Ubiquitin B

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  HEL-S-5polyubiquitin-B, epididymis secretory protein Li 5polyubiquitin B

• Tested Applications:

  WB

• Physical Properties:

  Liquid