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CHIT1 Antibody

CAT: 0223-18-448Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-18-448Size:100 µL
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Background
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
NCBI Gene ID
1118
Swiss Prot
Q13231
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
Affinity purification
Positive Control
U-251MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 52kDa
Fragment
IgG
Symbol
CHIT1
Positive Control 2
293T
Positive Control 3
Mouse spleen
Positive Control 4
Mouse skeletal muscle
NCBI Official Name
Chitinase 1 (chitotriosidase)
NCBI Organism
Homo sapiens
Other Product Names
CHIT1, plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase, OTTHUMP00000217085, OTTHUMP00000217084, OTTHUMP00000217083, MGC125322, FLJ00314, chitotriosidase-1, chitinase-1, chitinase 1 (chitotriosidase), CHIT, CHI3, CHITD
Tested Applications
WB, IHC
Physical Properties
Liquid

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