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PITX2 Antibody

CAT: 0223-18-358Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-18-358Size:100 µL
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Background
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI Gene ID
5308
Swiss Prot
Q99697
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX2 (NP_000316.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Transcription
Purification
Affinity purification
Positive Control
NCI-H490
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 39kDa
Fragment
IgG
Symbol
PITX2
Positive Control 2
HeLa
Positive Control 3
Mouse brain
Positive Control 4
Rat brain
NCBI Official Name
Paired-like homeodomain 2
NCBI Organism
Homo sapiens
Other Product Names
PITX2, RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, IGDS2, IRID2, Otlx2, RIEG1
Tested Applications
WB, IHC
Physical Properties
Liquid

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