LIG1 Antibody

• Background:

  This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  3978

• Swiss Prot:

  P18858

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 565-790 of human LIG1 (NP_000225.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  MCF7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 140kDa

• Fragment:

  IgG

• Symbol:

  LIG1

• Positive Control 2:

  A-549

• Positive Control 3:

  K-562

• Positive Control 4:

  Jurkat

• Positive Control 5:

  22Rv1

• Positive Control 6:

  Mouse testis

• NCBI Official Name:

  Ligase I, DNA, ATP-dependent

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  LIG1, MGC117397, MGC130025

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid