EWSR1 Antibody

• Background:

  This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t (11;22) (q24; q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

• NCBI Gene ID:

  2130

• Swiss Prot:

  Q01844

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human EWSR1 (NP_001156757.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Transcription

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 105kDa

• Fragment:

  IgG

• Symbol:

  EWSR1

• Positive Control 2:

  293T

• Positive Control 3:

  NCI-H460

• Positive Control 4:

  HeLa

• Positive Control 5:

  Mouse spleen

• Positive Control 6:

  Mouse thymus

• NCBI Official Name:

  EWS RNA-binding protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  EWSR1, AC002059.7, EWS, bK984G1.4

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid