CASP3 Antibody

CAT: 0223-16-751Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-16-751Size:100 µL
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Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
NCBI Gene ID
836
Swiss Prot
P42574
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human CASP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Jurkat
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 31kDa
Fragment
IgG
Symbol
CASP3
Positive Control 2
HeLa
Positive Control 3
293T
Positive Control 4
NIH/3T3
NCBI Official Name
Caspase 3, apoptosis-related cysteine peptidase
NCBI Organism
Homo sapiens
Other Product Names
Caspase-3 Antibody: CPP32, SCA-1, CPP32B, CPP32, Caspase-3, Apopain, CASP-3
Tested Applications
WB, IHC, IF, IP
Physical Properties
Liquid

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