TGFBR2 Antibody

• Background:

  This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

• NCBI Gene ID:

  7048

• Swiss Prot:

  P37173

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 23-280 of human TGFBR2 (NP_003233.4) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  HT-29

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 75kDa

• Fragment:

  IgG

• Symbol:

  TGFBR2

• Positive Control 2:

  A-549

• Positive Control 3:

  Mouse lung

• Positive Control 4:

  Mouse spleen

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Mouse kidney

• NCBI Official Name:

  Transforming growth factor, beta receptor II (70/80kDa)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TGFBR2, HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid