DHFR Antibody

• Background:

  Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1719

• Swiss Prot:

  P00374

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human DHFR (NP_000782.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 19kDa

• Fragment:

  IgG

• Symbol:

  DHFR

• Positive Control 2:

  22Rv1

• Positive Control 3:

  K-562

• Positive Control 4:

  HL-60

• Positive Control 5:

  THP-1

• Positive Control 6:

  Raji

• NCBI Official Name:

  Dihydrofolate reductase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DHFRP1, DYR, dihydrofolate reductase

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid