TNFR1 Antibody

• Background:

  This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

• NCBI Gene ID:

  7132

• Swiss Prot:

  P19438

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 22-211 of human TNFR1 (NP_001056.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Chemokines & Cytokines, Growth Factors, Immunology, Innate Immunity, Neuroscience, Signal Transduction, Inflammasomes

• Purification:

  Affinity purification

• Positive Control:

  A-549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 56kDa

• Fragment:

  IgG

• Symbol:

  TNFRSF1A

• Positive Control 2:

  Mouse lung

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily, member 1A

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TNFRSF1A, tumor necrosis factor-alpha receptor, tumor necrosis factor receptor type 1, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor binding protein 1, TNF-R-I, TNF-RI, TNFR-I, TNFR60, TNF-R55, TNFR55, TNF-R1, TNFR1, TNF-R, TNFAR, TBP1, p60, p55-R, p55, MGC19588, FPF, CD120a

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid