SIM2 Antibody

• Background:

  This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

• NCBI Gene ID:

  6493

• Swiss Prot:

  Q14190

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_033664.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Transcription

• Purification:

  Affinity purification

• Positive Control:

  U-251MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 56kDa

• Fragment:

  IgG

• Symbol:

  SIM2

• Positive Control 2:

  HepG2

• NCBI Official Name:

  Single-minded family bHLH transcription factor 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Single-minded homolog 2, short isoform, single-minded homolog 2, class E basic helix-loop-helix protein 15, OTTHUMP00000109044, bHLHe15, SIM, MGC119447, single-minded homolog 2 (Drosophila), SIM2, BHLHE15

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid