SIM2 Antibody

• Background :

  This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

• NCBI Gene ID :

  6493

• Swiss Prot :

  Q14190

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 342-525 of human SIM2 (NP_033664.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Neuroscience, Transcription

• Purification :

  Affinity purification

• Positive Control :

  U-251MG

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 56kDa

• Fragment :

  IgG

• Symbol :

  SIM2

• Positive Control 2 :

  HepG2

• NCBI Official Name :

  Single-minded family bHLH transcription factor 2

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Single-minded homolog 2, short isoform, single-minded homolog 2, class E basic helix-loop-helix protein 15, OTTHUMP00000109044, bHLHe15, SIM, MGC119447, single-minded homolog 2 (Drosophila), SIM2, BHLHE15

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid