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DLAT Antibody

CAT: 0223-15-588Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-15-588Size:100 µL
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Background
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC) . PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC) . In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
NCBI Gene ID
1737
Swiss Prot
P10515
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 87-270 of human DLAT (NP_001922.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 69kDa
Fragment
IgG
Symbol
DLAT
Positive Control 2
MCF7
Positive Control 3
HepG2
Positive Control 4
K-562
Positive Control 5
Mouse brain
Positive Control 6
Rat brain
NCBI Official Name
Dihydrolipoamide S-acetyltransferase
NCBI Organism
Homo sapiens
Other Product Names
DLAT, DLTA, PDC-E2, PDCE2
Tested Applications
WB, IHC
Physical Properties
Liquid

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