CAND1 Antibody

• Background:

  This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  55832

• Swiss Prot:

  Q86VP6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 136kDa

• Fragment:

  IgG

• Symbol:

  CAND1

• Positive Control 2:

  Mouse brain

• Positive Control 3:

  Mouse heart

• Positive Control 4:

  Mouse kidney

• Positive Control 5:

  Mouse liver

• Positive Control 6:

  Rat brain

• NCBI Official Name:

  Cullin-associated and neddylation-dissociated 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TIP120A, TIP120, TIP120A

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid