RIN2 Antibody

• Background :

  The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  54453

• Swiss Prot :

  Q8WYP3

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 596-895 of human RIN2 (NP_061866.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  293T

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 120kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  RIN2

• Positive Control 2 :

  A-549

• Positive Control 3 :

  HeLa

• Positive Control 4 :

  HepG2

• Positive Control 5 :

  Mouse heart

• Positive Control 6 :

  Mouse kidney

• NCBI Official Name :

  Ras and Rab interactor 2

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  MACS, RASSF4, ras and Rab interactor 2, RAB5 interacting protein 2, RAS association (RalGDS/AF-6) domain containing protein JC265, RAS association domain family 4, RAS inhibitor JC265, RAS interaction/interference protein 2

• Tested Applications :

  WB

• Physical Properties :

  Liquid