GHRL Antibody

• Background:

  This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin) . Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

• NCBI Gene ID:

  51738

• Swiss Prot:

  Q9UBU3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human GHRL (NP_057446.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Growth Factors, Neuroscience, Obesity, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 16kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  GHRL

• Positive Control 2:

  HL-60

• Positive Control 3:

  HeLa

• NCBI Official Name:

  Ghrelin and obestatin prepropeptide

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  MTLRP, appetite-regulating hormone, In2c-preproghrelin, ghrelin, growth hormone secretagogue receptor ligand, ghrelin/obestatin preprohormone, ghrelin/obestatin prepropeptide, growth hormone-releasing peptide, motilin-related peptide, prepro-appetite regulatory hormone, preproghrelin

• Tested Applications:

  WB

• Physical Properties:

  Liquid