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IL12RB1 Antibody

CAT: 0223-14-916Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-14-916Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
3594
Swiss Prot
P42701
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines, Immunology, Innate Immunity
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
IL12RB1
NCBI Official Name
Interleukin 12 receptor, beta 1
NCBI Organism
Homo sapiens
Other Product Names
IL12RB1, MGC34454, interleukin-12 receptor beta-1 chain, interleukin 12 receptor, beta 1, IL-12R-BETA1, IL12RB, IL-12 receptor beta component, CD212, IL12R
Tested Applications
IHC, IF
Physical Properties
Liquid

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