UMPS Antibody

• Background:

  This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID:

  7372

• Swiss Prot:

  P11172

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 100-260 of human UMPS (NP_000364.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HT-29

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 57kDa

• Fragment:

  IgG

• Symbol:

  UMPS

• Positive Control 2:

  U-87MG

• Positive Control 3:

  HeLa

• Positive Control 4:

  LO2

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Mouse kidney

• NCBI Official Name:

  Uridine monophosphate synthetase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  UMPS, OPRT, RP11-71H17.9

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid