SAG Antibody

• Background :

  Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

• NCBI Gene ID :

  6295

• Swiss Prot :

  P10523

• Host :

  Rabbit

• Reactivity :

  Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-405 of human SAG (NP_000532.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  Mouse eye

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 48kDa

• Fragment :

  IgG

• Symbol :

  SAG

• Positive Control 2 :

  Rat eye

• NCBI Official Name :

  S-antigen visual arrestin

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  RP47, S-AG, S-arrestin, 48 kDa protein, S-antigen; retina and pineal gland (arrestin), arrestin 1, retinal S-antigen (48 KDa protein), rod arrestin, rod photoreceptor arrestin

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid