ELANE Antibody

• Background:

  Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) . This gene is present in a gene cluster on chromosome 19.

• NCBI Gene ID:

  1991

• Swiss Prot:

  P08246

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 30-267 of human ELANE (NP_001963.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  LO2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 29kDa

• Fragment:

  IgG

• Symbol:

  ELANE

• Positive Control 2:

  Mouse brain

• NCBI Official Name:

  Elastase, neutrophil expressed

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ELANE, Bone marrow serine protease, ELA2, Elastase 2, neutrophil, Elastase-2, HLE, Medullasin, Granulocyte-derived elastase, Neutrophil elastase, NE, Human leukocyte elastase, PMN elastase, PMN-E, SCN1, Polymorphonuclear elastase, Elastase, neutrophil expressed, GE, Leukocyte elastase, Lysosomal elastase

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid