DKC1 Antibody

• Background:

  This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs) . This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  1736

• Swiss Prot:

  O60832

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human DKC1 (NP_001354.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 57kDa

• Fragment:

  IgG

• Symbol:

  DKC1

• Positive Control 2:

  22Rv1

• Positive Control 3:

  HepG2

• Positive Control 4:

  MCF7

• Positive Control 5:

  K-562

• NCBI Official Name:

  Dyskeratosis congenita 1, dyskerin

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DKC1, dyskeratosis congenita 1, dyskerin, DKC, NAP57, NOLA4, XAP101

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid