DKC1 Antibody

• Background :

  This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs) . This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  1736

• Swiss Prot :

  O60832

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human DKC1 (NP_001354.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  HeLa

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 57kDa

• Fragment :

  IgG

• Symbol :

  DKC1

• Positive Control 2 :

  22Rv1

• Positive Control 3 :

  HepG2

• Positive Control 4 :

  MCF7

• Positive Control 5 :

  K-562

• NCBI Official Name :

  Dyskeratosis congenita 1, dyskerin

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  DKC1, dyskeratosis congenita 1, dyskerin, DKC, NAP57, NOLA4, XAP101

• Tested Applications :

  WB, IHC, IF

• Physical Properties :

  Liquid