KRAS Antibody, KO Validated

• Background :

  This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

• NCBI Gene ID :

  3845

• Swiss Prot :

  P01116

• Host :

  Rabbit

• Reactivity :

  Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 30-188 of human KRAS (NP_004976.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Validation :

  Antibody is Knockout validated.

• Field of Research :

  Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  KRAS

• NCBI Official Name :

  Kirsten rat sarcoma viral oncogene homolog

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  KRAS, C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS3, RASK2, NS, CFC2

• Tested Applications :

  WB

• Physical Properties :

  Liquid