MAPK9 Antibody, KO Validated

• Background:

  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

• NCBI Gene ID:

  5601

• Swiss Prot:

  P45984

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human MAPK9 (NP_002743.3) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Immunology, Innate Immunity, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF-7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 54kDa

• Fragment:

  IgG

• Symbol:

  MAPK9

• Positive Control 2:

  DU145

• Positive Control 3:

  THP-1

• Positive Control 4:

  Mouse liver

• NCBI Official Name:

  Mitogen-activated protein kinase 9

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  MAPK9, stress-activated protein kinase JNK2, SAPK, PRKM9, p54aSAPK, p54a, OTTHUMP00000161543, OTTHUMP00000161542, mitogen-activated protein kinase 9, MAPK 9, MAP kinase 9, Jun kinase, JNK-55, JNK2BETA, JNK2B, JNK2ALPHA, JNK2A, JNK2, c-Jun N-terminal kinase 2, c-Jun kinase 2, SAPK1A

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid