EIF4EBP1 Antibody, KO Validated

• Background:

  This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

• NCBI Gene ID:

  1978

• Swiss Prot:

  Q13541

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human EIF4EBP1 (NP_004086.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 17kDa

• Fragment:

  IgG

• Symbol:

  EIF4EBP1

• Positive Control 2:

  HeLa

• Positive Control 3:

  SH-SY5Y

• Positive Control 4:

  NIH/3T3

• Positive Control 5:

  Mouse fat

• Positive Control 6:

  Mouse heart

• NCBI Official Name:

  Eukaryotic translation initiation factor 4E binding protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  4E-BP1 Antibody: BP-1, 4EBP1, 4E-BP1, PHAS-I, Eukaryotic translation initiation factor 4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid