CRKL Antibody, KO Validated

• Background:

  This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

• NCBI Gene ID:

  1399

• Swiss Prot:

  P46109

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Cancer, Immunology, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  LO2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 37kDa

• Fragment:

  IgG

• Symbol:

  CRKL

• Positive Control 2:

  Jurkat

• Positive Control 3:

  SKOV3

• Positive Control 4:

  Mouse brain

• Positive Control 5:

  Rat heart

• NCBI Official Name:

  V-crk avian sarcoma virus CT10 oncogene homolog-like

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  CRKL, v-crk sarcoma virus CT10 oncogene homolog (avian) -like, v-crk avian sarcoma virus CT10 oncogene homolog-like

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid