TYMS Antibody

• Background:

  Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

• NCBI Gene ID:

  7298

• Swiss Prot:

  P04818

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human TYMS (NP_001062.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  A-431

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 36kDa

• Fragment:

  IgG

• Symbol:

  TYMS

• Positive Control 2:

  Jurkat

• Positive Control 3:

  DU145

• Positive Control 4:

  Mouse kidney

• Positive Control 5:

  Mouse spleen

• NCBI Official Name:

  Thymidylate synthetase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TYMS, HsT422, MGC88736, TMS, TS, TSase, HST422

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid