IARS Antibody

• Background :

  Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found.

• NCBI Gene ID :

  3376

• Swiss Prot :

  P41252

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1158-1262 of human IARS (NP_002152.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  HeLa

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 144kDa

• Fragment :

  IgG

• Symbol :

  IARS

• Positive Control 2 :

  HepG2

• Positive Control 3 :

  HT-29

• Positive Control 4 :

  HL-60

• Positive Control 5 :

  Jurkat

• NCBI Official Name :

  Isoleucyl-tRNA synthetase

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  GRIDHH1, ILERS, ILRS, IRS, PRO0785, IARS, isoleucine--tRNA ligase, cytoplasmic, isoleucine tRNA ligase 1, cytoplasmic

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid