IARS Antibody

• Background:

  Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found.

• NCBI Gene ID:

  3376

• Swiss Prot:

  P41252

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1158-1262 of human IARS (NP_002152.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HeLa

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 144kDa

• Fragment:

  IgG

• Symbol:

  IARS

• Positive Control 2:

  HepG2

• Positive Control 3:

  HT-29

• Positive Control 4:

  HL-60

• Positive Control 5:

  Jurkat

• NCBI Official Name:

  Isoleucyl-tRNA synthetase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  GRIDHH1, ILERS, ILRS, IRS, PRO0785, IARS, isoleucine--tRNA ligase, cytoplasmic, isoleucine tRNA ligase 1, cytoplasmic

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid