RAP1A Antibody

• Background:

  This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs) . The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  5906

• Swiss Prot:

  P62834

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAP1A (NP_002875.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-87MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 21kDa

• Fragment:

  IgG

• Symbol:

  RAP1A

• Positive Control 2:

  HL-60

• Positive Control 3:

  Mouse lung

• Positive Control 4:

  Mouse kidney

• Positive Control 5:

  Rat kidney

• Positive Control 6:

  Rat brain

• NCBI Official Name:

  Ras-related protein Rap-1A

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid