TMEM41B (NT) Antibody

• Background:

  TMEM41B Antibody: TMEM41B is required for autophagosome formation and participates in early stages of autophagosome biogenesis at the ER membrane probably via mobilization of neutral lipids from lipid droplets. TMRM41B is a critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. It is required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles.

• NCBI Gene ID:

  440026

• Swiss Prot:

  Q5BJD5

• Accession Number:

  Q5BJD5

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  9567

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  TMEM41B Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1203 – A549 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Horse (100%) ; Chimpanzee (100%) .

• Buffer:

  TMEM41B Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TMEM41B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TMEM41B

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Transmembrane protein 41B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Moretti et al. EMBO Rep. 2018; 19 (9) :e45889.

• Background Reference 02:

  Shoemaker et al. PLoS Biol. 2019; 17 (4) :e2007044.

• Background Reference 03:

  Schneider et al. Cell 2021; 184 (1) :120-132.

• Background Reference 04:

  Hoffmann et al. Cell 2021; 184 (1) :133-148.e20.

• Other Product Names:

  TMEM41B Antibody: Transmembrane protein 41B, Protein stasimon, TMEM41B, KIAA0033.

• Tested Applications:

  ELISA, IF, WB

• Protein ID:

  74741383

• Physical Properties:

  Liquid