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IRF7 Antibody

CAT: 0223-8991-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8991-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IRF7 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
NCBI Gene ID
3665
Swiss Prot
Q92985
Accession Number
Q92985
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
8991
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KO Validation (Figure 1) : Anti-IRF7 antibodies (8991) specificity was further verified by IRF7 specific knockout. IRF7 was disrupted in IRF7 knockout A549 cells as compared to that in control wild type cells. KO Validation (8991)
Field of Research
Innate Immunity
Purification
IRF7 Antibody is Protein A purified.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Buffer
IRF7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IRF7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Several isoforms of IRF7 are known to exist.
Isoform
Human IRF7 has 4 isoforms, including isoform A (503aa, 54kD), isoform B (474aa, 52kD), isoform C (164aa, 18kD) and isoform D (516aa, 56kD) . Mouse IRF7 has one isoform (457aa, 51kD) and Rat IRF7 also has one isoform (456aa, 51kD) . 8991 can detect human isoforms and mouse, and possibly can detect rat.
Symbol
IRF7
Positive Control 2
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 3
Cat. No. 1211 - HepG2 Cell Lysate
NCBI Official Name
Interferon regulatory factor 7
NCBI Organism
Homo sapiens
Background Reference 01
Malmgaard. J. Interferon & Cyto. Res. 2004; 24:439-54.
Background Reference 02
Sato et al. Immunity 2000; 13:539-48.
Background Reference 03
Fitzgerald et al. J. Exp. Med. 2003; 198:1043-55.
Background Reference 04
Honda et al. Proc. Natl. Acad. Sci. USA 2004; 101:15416-21.
Other Product Names
IRF7 Antibody: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7
Tested Applications
ELISA, WB, IHC-P
Protein ID
116242593
Physical Properties
Liquid

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