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HRIP3 Antibody

CAT: 0223-8963-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8963-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HRIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-κB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
NCBI Gene ID
11035
Swiss Prot
Q9Y572
Accession Number
Q9Y572
Host
Rabbit
Reactivity
Human
Immunogen
8963
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
HRIP3 Antibody is Protein A purified.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/ml
Buffer
HRIP3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HRIP3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Several isoforms of hRIP3 are known to exist.
Isoform
Human RIP3 has 3 isoforms, including isoform 1 (518aa, 57kD), isoform 2 (252aa, 28kD) and isoform 3 (231aa, 25kD) . Mouse RIP3 has one isoform (486aa, 53kD) and Rat RIP3 also has one isoform (478aa, 52kD) . 8963 can detect only human isoform 1 and cannot detect other human isoforms, mouse and rat isoforms.
Symbol
Ripk3
Positive Control 2
Cat. No. 1224 - Daudi Cell Lysate
Positive Control 3
Cat. No. 1208 - THP-1 Cell Lysate
NCBI Official Name
Receptor-interacting serine-threonine kinase 3
NCBI Organism
Homo sapiens
Background Reference 01
Yu et al. Curr Biol. 1999;9 (10) :539-42.
Background Reference 02
Sun et al. J Biol Chem. 1999;274 (24) :16871-5.
Background Reference 03
Pazdernik et al. Mol Cell Bio. 1999; 19 (10) :6500-8 (WD0102)
Other Product Names
HRIP3 Antibody: Rip3, AW107945, 2610528K09Rik, RIP-like protein kinase 3, RIP-3
Tested Applications
ELISA, IF, IHC-P, WB
Protein ID
205371831
Physical Properties
Liquid

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