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ETV4 Antibody

CAT: 0223-8535-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8535-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ETV4 Antibody: ETV4, along with the related proteins ETV1 and ETV5, form the PEA3 subfamily of the E26 transformation-specific (ETS) transcription factor family (1) . ETV4 is thought to play roles in embryonic kidney development and fertility (2,3), and is also thought to be an oncoprotein in multiple cancers (4) .
NCBI Gene ID
2118
Swiss Prot
P43268
Accession Number
NP_001977
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ETV4 antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human ETV4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ETV4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish: (72%)
Buffer
ETV4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ETV4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of ETV4 are known to exist. This antibody will only detect the two longest isoforms.
Symbol
ETV4
Positive Control 2
Cat. No. 1202 - A431 Cell Lysate
NCBI Official Name
ETS translocation varinat 4
NCBI Organism
Homo sapiens
Background Reference 01
Xin JH, Cowie A, LAchance P, et al. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev. 1992; 6:481-96.
Background Reference 02
Lu BC, Cebrian C, Chi X, et al. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat. Genet. 2009; 41:1295-302.
Background Reference 03
Laing MA, Coonrod S, Hinton BT, et al. Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Mol. Cell. Biol. 2000; 20:9337-45.
Background Reference 04
Oh S, Shin S, and Janknecht R. ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta 2012: 1826:1-12.
Other Product Names
ETV4 Antibody: ETS variant 4, E1AF, PEA3, E1A-F, PEAS3
Tested Applications
ELISA, WB
Protein ID
24307883
Physical Properties
Liquid

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