ETV6 Antibody

• Background :

  This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

• NCBI Gene ID :

  2120

• Swiss Prot :

  P41212

• Accession Number :

  P41212

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This ETV6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the Central region of human ETV6.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  53 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  ETV6

• NCBI Official Name :

  Transcription factor ETV6

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Otsubo, K., et al. Cancer Genet. Cytogenet. 202 (1) :22-26 (2010)

• Background Reference 02 :

  Roukens, M.G., et al. Nat. Cell Biol. 12 (10) :933-942 (2010)

• Background Reference 03 :

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04 :

  Gascon, E., et al. J. Neurosci. 30 (37) :12414-12423 (2010)

• Other Product Names :

  Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel, ETV6, TEL, TEL1

• Tested Applications :

  WB

• Protein ID :

  730927

• Physical Properties :

  Liquid