ETV6 Antibody

ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. This protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

2120

P41212

NP_001978

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ETV6.

Unconjugated

Primary Antibodies

Transcription, Cancer

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1205 - Jurkat Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ETV6 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

53 kDa

ETV6 antibody can be used for detection of ETV6 by ELISA at 1:312500. ETV6 antibody can be used for detection of ETV6 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

ETV6

Ets variant 6

Homo sapiens

Rubnitz, J.E., (2008) J. Clin. Oncol. 26 (13), 2186-2191.

ETV6, TEL, TEL/ABL

ELISA, WB

4503611