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ALSFTD Antibody

CAT: 0223-8469-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8469-01Size:0.02 mg
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Background
ALSFTD (C9orf72) is considered to play a role in gender determination (1) . Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG (2) . Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster (3,4) .
NCBI Gene ID
203228
Swiss Prot
Q96LT7
Accession Number
NP_060795
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
ALSFTD Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
ALSFTD Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ALSFTD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
Symbol
ALSFTD
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Chromosome 9 open reading frame 72
NCBI Organism
Homo sapiens
Background Reference 01
Takada LT and Sha SJ. Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimers Res. Ther. 2012; 4:38.
Background Reference 02
Coon EA, Whitwell JL, Parisi JE, et al. Right temporal variant frontotemporal dementia with motor neuron disease. J. Clin. Neurosci. 2012; 19:85-91.
Background Reference 03
Snowden JS, Rollinson S, Thompson JC, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012; 135:693-708.
Background Reference 04
Wen X, Tan W, Westergard T, et al. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron 2014; 84:1213-25.
Other Product Names
Amyotrophic lateral sclerosis with frontotemporal dementia, chromosome 9 open reading frame 72, C9orf72
Tested Applications
ELISA, WB, ICC
Protein ID
37039612
Physical Properties
Liquid

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