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DIS3L2 Antibody

CAT: 0223-8347-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8347-01Size:0.02 mg
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Background
The exosome is involved in a multitude of cellular RNA processing and degradation events (1) . DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2) . DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3) . DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4) . DIS3L2 mutations have also been associated with sporadic Wilms tumors (3) .
NCBI Gene ID
129563
Swiss Prot
Q8IYB7
Accession Number
NP_689596
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
DIS3L2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Buffer
DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DIS3L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.
Symbol
DIS3L2
NCBI Official Name
DIS3 like 3'-5' exoribonuclease 2
NCBI Organism
Homo sapiens
Background Reference 01
Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107:451-64.
Background Reference 02
Brouwer R, Allmang C, Raijmakers R, et al. Three novel components of the human exosome. J. Biol. Chem. 2001; 276:6177-84.
Background Reference 03
Astuti D, Morris MR, Cooper WN, et al. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. Nat. Genet. 2012; 44:277-84.
Background Reference 04
Malecki M, Viegas SC, Carneiro T, et al. The exonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. EMBO J. 2013; 32:1842-54.
Other Product Names
DIS3 like 3'-5' exoribonuclease 2, FAM6A, PRLMNS
Tested Applications
ELISA, WB
Protein ID
134288890
Physical Properties
Liquid

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