DIS3 Antibody

• Background:

  DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

• NCBI Gene ID:

  22894

• Swiss Prot:

  Q9Y2L1

• Accession Number:

  NP_055768

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  DIS3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1316 - Human Ovary Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DIS3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of DIS3 are known to exist.

• Symbol:

  DIS3

• NCBI Official Name:

  DIS3 mitotic control homolog (S. cerevisiae)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen CY, Gherzi R, Ong SE, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001; 107:451-64.

• Background Reference 02:

  Brouwer R, Allmang C, Raijmakers R, et al. Three novel components of the human exosome. J. Biol. Chem. 2001; 276:6177-84.

• Background Reference 03:

  Schneider C, Anderson JT, Tollervey D, et al. The exosome subunit Rrp44 plays a direct role in RNA substrate recognition. Mol. Cell 2007; 27:324-31.

• Background Reference 04:

  Murakami H, Goto DB, Toda T, et al. Ribonuclease activity of DIS3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function. PLoS ONE 2007; 2:317.

• Other Product Names:

  DIS3 Antibody: RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  190014623

• Physical Properties:

  Liquid