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SLC36A2 Antibody

CAT: 0223-8341-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8341-01Size:0.02 mg
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Background
SLC36A2 is a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2) . Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2) . SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2) . Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3) .
NCBI Gene ID
153201
Swiss Prot
Q495M3
Accession Number
NP_861441
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Neuroscience
Purification
SLC36A2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1319 - Human Stomach Tissue Lysate
Concentration
1 mg/mL
Buffer
SLC36A2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLC36A2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.
Symbol
SLC36A2
NCBI Official Name
Solute carrier family 36 (proton/amino acid symporter), member 2
NCBI Organism
Homo sapiens
Background Reference 01
Boll M, Foltz M, Rubio-Aliaga I, et al. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J. Biol. Chem. 2002; 277:22966-73.
Background Reference 02
Rubio-Aliaga I, Boll M, Vogt Weisenhorn DM, et al. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. J. Biol. Chem. 2004; 279:2754-60.
Background Reference 03
Broer S, Bailey CG, Kowalczuk S, et al. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J. Clin. Invest. 2008; 118:3881-92.
Other Product Names
Solute carrier family 36 (proton/amino acid symporter) member 2, proton-coupled amino acid transporter 2, PAT2, TRAMD1
Tested Applications
ELISA, WB
Protein ID
222418631
Physical Properties
Liquid

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