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VTI1a Antibody

CAT: 0223-8287-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8287-01Size:0.02 mg
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Background
Vesicle transport through interaction with t-SNAREs homolog 1 (VTI1a and VTI1b) are involved in vesicular transport from the late endosomes to the trans-Golgi network (1) . They are both localized in the trans-Golgi network, with VTI1a also found in the Golgi apparatus and VTI1b in endosomes (2,3) . VTI1a mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane and promotes fusion of the lipid bilayers (4) . VTI1a may be concerned with increased secretion of cytokines associated with cellular senescence (5) .
NCBI Gene ID
143187
Swiss Prot
Q96AJ9
Accession Number
NP_660207
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
VTI1a antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
VTI1a antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VTI1a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
VTI1a antibody is human, mouse and rat reactive. At least two isoforms of VTI1a are known to exist; this antibody will detect both isoforms. VTI1a antibody is predicted to not cross-react with VTI1b.
Symbol
VTI1a
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Vesicle transport through interaction with t-SNAREs 1A
NCBI Organism
Homo sapiens
Background Reference 01
Fischer VM and Stevens TH. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. J. Biol. Chem. 1998; 273:2624-30.
Background Reference 02
Kreykenbohm V, Wenzel D, Antonin W et al. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Eur. J. Cell Biol. 2002; 81:273-80.
Background Reference 03
Antonin W, Riedel D, von Mollard GF, et al. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. J. Neurosci. 2000; 20:5724-32.
Background Reference 04
Atlashkin V, Kreykenbohm V, Eskelinen EL, et al. Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol. Cell Biol. 2003; 23:5198-207.
Other Product Names
Vesicle transport through interaction with t-SNAREs 1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2
Tested Applications
ELISA, WB, IHC-P
Protein ID
113374156
Physical Properties
Liquid

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