LRRC8A Antibody

• Background :

  The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2) . LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1) . LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3) .

• NCBI Gene ID :

  56262

• Swiss Prot :

  Q8IWT6

• Accession Number :

  NP_062540

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Stem Cell, Signal Transduction

• Purification :

  LRRC8A antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  LRRC8A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Observed Molecular Weight :

  Multiple other LRRC8A antibodies also show a ~95kD band

• Fragment :

  IgG

• Specificity :

  LRRC8A antibody is human, mouse and rat reactive.

• Symbol :

  LRRC8A

• NCBI Official Name :

  Leucine rich repeat containing 8 family, member A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Sawada A, Takihara Y, Kim JY, et al. A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. J. Clin. Invest. 2003; 112:1707-13.

• Background Reference 02 :

  Kubota K, Kim JY, Sawada A, et al. LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins. FEBS Lett. 2004; 564:147-52.

• Background Reference 03 :

  Voss FK, Ullrich F, Munch J, et al. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 2014; 344:634-8.

• Other Product Names :

  Leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, LRRC8, AGM5

• Tested Applications :

  ELISA, WB, IHC-P

• Protein ID :

  62241040

• Physical Properties :

  Liquid