LRRC8A Antibody

• Background:

  The leucine rich repeat containing 8 family member A protein (LRRC8A) belongs the LRRC8 family of proteins within the LRR superfamily of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions (1,2) . LRRC8A is a four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation (1) . LRRC8A has also been shown to be an essential component of the volume-regulated anion channel VRAC (3) .

• NCBI Gene ID:

  56262

• Swiss Prot:

  Q8IWT6

• Accession Number:

  NP_062540

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Signal Transduction

• Purification:

  LRRC8A antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  LRRC8A antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  LRRC8A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Observed Molecular Weight:

  Multiple other LRRC8A antibodies also show a ~95kD band

• Fragment:

  IgG

• Specificity:

  LRRC8A antibody is human, mouse and rat reactive.

• Symbol:

  LRRC8A

• NCBI Official Name:

  Leucine rich repeat containing 8 family, member A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sawada A, Takihara Y, Kim JY, et al. A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. J. Clin. Invest. 2003; 112:1707-13.

• Background Reference 02:

  Kubota K, Kim JY, Sawada A, et al. LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins. FEBS Lett. 2004; 564:147-52.

• Background Reference 03:

  Voss FK, Ullrich F, Munch J, et al. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 2014; 344:634-8.

• Other Product Names:

  Leucine rich repeat containing 8 family member A, leucine-rich repeat-containing protein 8A, LRRC8, AGM5

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  62241040

• Physical Properties:

  Liquid