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IZUMO1 Antibody

CAT: 0223-8233-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8233-01Size:0.02 mg
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Background
IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2) . IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3) . Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4) .
NCBI Gene ID
284359
Swiss Prot
Q8IYV9
Accession Number
NP_872381
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
IZUMO1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (82%), Mouse: (81%)
Buffer
IZUMO1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IZUMO1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Transmembrane protein, also multiple other IZUMO1 antibodies also show a ~52kD band
Fragment
IgG
Specificity
IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist; this antibody will detect the two longest isoforms.
Symbol
IZUMO1
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
Izumo sperm-egg fusion 1
NCBI Organism
Homo sapiens
Background Reference 01
Inoue N, Hamada D, Kamikubo H, et al. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development 2013; 140:3221-9.
Background Reference 02
Inoue N, Ikawa M, and Okabe M. The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian J. Androl. 2011; 13:81-7.
Background Reference 03
Xing WJ, Han BD, Wu Q, et al. Molecular cloning and characterization of Izumo1 gene from sheep and cashmere goat reveal alternative splicing. Mol. Biol. Rep. 2011; 38:1995-2006.
Background Reference 04
Inoue N, Ikawa M, Isotani A, et al. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 2005; 434:234-8.
Other Product Names
Izumo sperm-egg fusion 1, IZUMO, Izumo sperm-egg fusion protein 1, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo
Tested Applications
ELISA, WB, IHC-P
Protein ID
194097475
Physical Properties
Liquid

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