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LSD1 Antibody

CAT: 0223-8223-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8223-01Size:0.02 mg
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Background
Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1) . Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2) . LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4) . Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3) . LSD1-mediated histone demethylation thus may have significant effects on gene expression.
NCBI Gene ID
23028
Swiss Prot
O60341
Accession Number
NP_001009999
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
8223
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
LSD1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Buffer
LSD1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LSD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
At least two isoforms of LSD1 are known to exist; this antibody detects both.
Isoform
Human LSD1 has 2 isoforms, including isoform 1 (852aa, 93kD) and isoform 2 (876aa, 95kD) . Mouse LSD1 has one isoform (853aa, 93kD) and Rat LSD1 also has one isoform (872aa, 95kD) . 8223 can detect LSD1 in human, mouse and rat.
Symbol
KDM1A
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Lysine (K) -specific demethylase 1 A
NCBI Organism
Homo sapiens
Background Reference 01
Shi et al. Cell 2004; 119:941-53.
Background Reference 02
Kouzarides et al. Curr. Opin. Genet. Dev. 2002; 12:198-209.
Background Reference 03
Shi et al. Mol. Cell 2005; 19:857-64.
Background Reference 04
Nakamura et al. Mol. Cell 2002; 10:1119-28.
Other Product Names
Lysine-specific histone demethylase, amine oxidase flavin containing domain protein 2, AOF2
Tested Applications
ELISA, WB, IHC-P
Protein ID
58761544
Physical Properties
Liquid

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