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GOLGIN97 Antibody

CAT: 0223-8215-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8215-01Size:0.02 mg
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Background
GOLGIN97 was initially isolated as a Golgi complex autoantigen associated with Sjogren's syndrome, a chronic autoimmune disease in which the body's white blood cells destroy the exocrine glands, specifically the salivary and lacrimal glands (1,2) . GOLGIN97 plays a role as a tethering molecule in endosome to the trans-Golgi network (TGN) retrograde traffic (3) . FIP1/RCP binding to GOLGIN97 is required for tethering and fusion of recycling endosome retrograde transport vesicles to the TGN (4) .
NCBI Gene ID
2800
Swiss Prot
Q92805
Accession Number
NP_002068
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Immunology
Purification
GOLGIN97 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1319 - Human Stomach Tissue Lysate
Concentration
1 mg/mL
Buffer
GOLGIN97 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GOLGIN97 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Heavily post-translationally modifed, multiple independent GOLGIN97 antibodies show bands at ~120kDa
Fragment
IgG
Specificity
GOLGIN97 antibody is human, mouse and rat reactive. At least two isoforms of GOLGIN97 are known to exist; this antibody will detect only the longer isoform. GOLGIN97 antibody is predicted to not cross-react with other GOLGIN family proteins.
Symbol
GOLGA1
NCBI Official Name
Golgin A1
NCBI Organism
Homo sapiens
Background Reference 01
Griffith KJ, Chan EK, Lung CC, et al. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome. Arthritis Rheum. 1997; 40:1693-702.
Background Reference 02
Borchers AT, Naguwa SM, Keen CL, et al. Immunopathogenesis of Sjogren's syndrome. Clin. Rev. Allergy Immunol. 2003; 25:89-104.
Background Reference 03
Lu L, Tai G, and Hong W. Autoantigen Golgin-97, and effector of ARL1 GTPase, participates in traffic from the endosome to the trans-Golgi network. Mol. Biol. Cell 2004; 15:4426-43.
Background Reference 04
Jing J, Junutula JR, Wu C, et al. FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network. Mol. Biol. Cell 2010; 21:3041-53.
Other Product Names
Golgin subfamily A member 1, GOLGA1, GOLGIN A1, GOLGIN-97
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4504063
Physical Properties
Liquid

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