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UBD Antibody

CAT: 0223-8185-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8185-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2) . UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3) . It may also regulate cell growth during dendritic cell or B cell activation and development (4,5) .
NCBI Gene ID
10537
Swiss Prot
O15205
Accession Number
NP_006389
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Immunology
Purification
UBD antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (81%)
Buffer
UBD antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
UBD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
UBD antibody is human specific.
Symbol
UBD
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
Ubiquitin D
NCBI Organism
Homo sapiens
Background Reference 01
Ocklenburg F, Moharregh-Khiabani D, Geffers R, et al. UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells. Lab. Invest. 2006; 86:724-37.
Background Reference 02
Cook WJ, Jeffrey LC, Carson M, et al. Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2) . J. Biol. Chem. 1992; 267:16467-71.
Background Reference 03
Rahighi S, Ikeda F, Kawasaki M, et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009;136:1098-109.
Background Reference 04
Cort L, Habib M, Eberwine RA, et al. Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats. Genes Immun. 2014; 15:168-75.
Other Product Names
Ubiquitin D, Diubiquitin, FAT10, GABBR1, UBD-3, Ubiquitin-like protein FAT10
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
222352096
Physical Properties
Liquid

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