C2CD3 Antibody

CAT: 0223-8169-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-8169-01Size:0.02 mg
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Background
C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1) . It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3) . C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5) .
NCBI Gene ID
26005
Swiss Prot
Q4AC94
Accession Number
NP_001273506
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Signal Transduction
Purification
C2CD3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
C2CD3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
C2CD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
C2CD3 antibody is human, mouse and rat reactive.
Symbol
C2CD3
NCBI Official Name
C2 calcium-dependent domain containing 3
NCBI Organism
Homo sapiens
Background Reference 01
Hoover AN, Wynkoop A, Zeng H, et al. C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 2008; 135:4049-58.
Background Reference 02
Ye X, Zeng H, Ning G, et al. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc. Natl. Acad. Sci. USA 2014; 111:2164-9.
Background Reference 03
Thauvin-Robinet C, Lee JS, Lopez E, et al. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat. Genet. 2014; 46:905-11.
Background Reference 04
Balestra FR, Strnad P, Fluckiger I, et al. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev. Cell 2013; 25:555-71.
Other Product Names
C2 calcium-dependent domain containing 3, C2 domain-containing protein 3
Tested Applications
ELISA, WB
Protein ID
148596944
Physical Properties
Liquid

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