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AJAP1 Antibody

CAT: 0223-8163-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8163-01Size:0.02 mg
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Background
The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration (1) . It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium (1,2) . AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation (3) . This facilitates the dissolution of adherens junctions with an increase in cell motility (3,4) .
NCBI Gene ID
55966
Swiss Prot
Q9UKB5
Accession Number
NP_061324
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Cancer
Purification
AJAP1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
AJAP1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AJAP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
AJAP1 antibody is human, mouse and rat reactive.
Symbol
AJAP1
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
Adherens junctions associated protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Zeng L, Fee BE, Rivas MV, et al. Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review) . Int. J. Oncol. 2014; 45:13-7.
Background Reference 02
Han L, Zhang KL, Zhang JX, et al. AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci. Ther. 2014; 20:429-37.
Background Reference 03
Gross JC, Schreiner A, Engels K, et al. E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1. Mol. Biol. Cell 2009; 20:3598-607.
Background Reference 04
Lin N, Di C, Bortoff K, et al. Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol. Cancer Res. 2012; 10:208-17.
Other Product Names
Adherens junctions associated protein 1, Membrane protein shrew-1, MOT8, SHREW1
Tested Applications
ELISA, WB, ICC
Protein ID
9055278
Physical Properties
Liquid

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