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SLC29A3 Antibody

CAT: 0223-8129-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8129-01Size:0.02 mg
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Background
SLC29A3 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A3 is a transmembrane glycoprotein that localizes to the lysosomal membrane and is a broad selectivity, low affinity nucleoside transporter (3) . Mutations in the SLC29A3 gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism (4) . A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus (5) .
NCBI Gene ID
55315
Swiss Prot
Q9BZD2
Accession Number
NP_060814
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Homeostasis
Purification
SLC29A3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1410 - Mouse Bladder Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Buffer
SLC29A3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLC29A3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLC29A3 antibody is human, mouse and rat reactive. At least two isoforms of SLC29A3 are known to exist; this antibody will detect both isoforms. SLC29A3 antibody is predicted to not cross-react with other SLC29 proteins.
Symbol
SLC29A3
NCBI Official Name
Solute carrier family 29 (equilibrative nucleoside transporter), member 3
NCBI Organism
Homo sapiens
Background Reference 01
Hyde RJ, Cass CE, Young JD, et al. The ENT family of eukaryotic nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol. Membr. Biol. 2001; 18:53-63.
Background Reference 02
Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.
Background Reference 03
Baldwin SA, Yao SY, Hyde RJ, et al. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 2005; 280:15880-7.
Background Reference 04
Priya TP, Philip N, Molho-Pessach V, et al. H syndrome: novel and recurrent mutations in SLC29A3. Br. J. Dermatol. 2010; 162:1132-4.
Other Product Names
Solute carrier family 29 member 3, Equilibrative nucleoside transporter 3, ENT3, HCLAP, HJCD, PHID
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
148596922
Physical Properties
Liquid

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