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MALT1 Antibody

CAT: 0223-8097-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8097-01Size:0.02 mg
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Background
MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21; q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .
NCBI Gene ID
10892
Swiss Prot
Q9UDY8
Accession Number
NP_006776
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology
Purification
MALT1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
MALT1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MALT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.
Symbol
MALT1
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Mucosa associated lymphoid tissue lymphoma translocation gene 1
NCBI Organism
Homo sapiens
Background Reference 01
Dielamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t (11;18) (q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93:3601-9.
Background Reference 02
Lin X and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 2004; 16:429-35.
Background Reference 03
Rosebeck S, Rehman AO, Lucas PC, et al. From MALT lymphoma to the CBM signalsome: three decades of discovery. Cell Cycle 2011; 10:2485-96.
Background Reference 04
Staal J, Bekaert T, and Beyaert R. Regulation of NF-kB signaling by caspases and MALT1 paracaspase. Cell Res. 21:40-54.
Other Product Names
Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
5803078
Physical Properties
Liquid

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