MALT1 Antibody

• Background:

  MALT1 was initially identified as a novel gene that was recurrently rearranged in t (11;18) (q21; q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1) . MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2,3) . MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4) .

• NCBI Gene ID:

  10892

• Swiss Prot:

  Q9UDY8

• Accession Number:

  NP_006776

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology

• Purification:

  MALT1 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  MALT1 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MALT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  MALT1 antibody is human, mouse and rat reactive. At least two isoforms of MALT1 are known to exist; this antibody will detect both isoforms.

• Symbol:

  MALT1

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Mucosa associated lymphoid tissue lymphoma translocation gene 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dielamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t (11;18) (q21; q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93:3601-9.

• Background Reference 02:

  Lin X and Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 2004; 16:429-35.

• Background Reference 03:

  Rosebeck S, Rehman AO, Lucas PC, et al. From MALT lymphoma to the CBM signalsome: three decades of discovery. Cell Cycle 2011; 10:2485-96.

• Background Reference 04:

  Staal J, Bekaert T, and Beyaert R. Regulation of NF-kB signaling by caspases and MALT1 paracaspase. Cell Res. 21:40-54.

• Other Product Names:

  Mucosa associated lymphoid tissue lymphoma translocation 1, IMD12, MLT, MLT1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  5803078

• Physical Properties:

  Liquid