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SLC1A7 Antibody

CAT: 0223-8083-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8083-01Size:0.02 mg
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Background
The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1) . More recent evidence indicates that is it widely expressed in peripheral tissues, also (2) . Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3) . In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4) .
NCBI Gene ID
6512
Swiss Prot
O00341
Accession Number
NP_001274524
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
SLC1A7 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1285 - C2C12 Cell Lysate
Concentration
1 mg/mL
Buffer
SLC1A7 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLC1A7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.
Symbol
SLC1A7
NCBI Official Name
Solute carrier family 1 (glutamate transporter), member 7
NCBI Organism
Homo sapiens
Background Reference 01
Arriza JL, Eliasof S, Kavanaugh MP, et al. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 1997; 94:4155-60.
Background Reference 02
Lee A, Anderson AR, Stevens M, et al. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Eur. J. Histochem. 2013; 57:e11.
Background Reference 03
Schneider N, Cordeiro S, Machtens JP, et al. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 2014; 289:1815-24.
Background Reference 04
Boehmer C, Rajamanickam J, Schniepp R, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem. Biophys. Res. Commun. 2005; 329:738-42.
Other Product Names
Solute carrier family 1 (glutamate transporter) member 7, AAAT, excitatory amino acid transporter 5, EAAT5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
567316146
Physical Properties
Liquid

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