SLC1A7 Antibody

• Background:

  The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1) . More recent evidence indicates that is it widely expressed in peripheral tissues, also (2) . Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3) . In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4) .

• NCBI Gene ID:

  6512

• Swiss Prot:

  O00341

• Accession Number:

  NP_001274524

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  SLC1A7 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1285 - C2C12 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  SLC1A7 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SLC1A7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.

• Symbol:

  SLC1A7

• NCBI Official Name:

  Solute carrier family 1 (glutamate transporter), member 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Arriza JL, Eliasof S, Kavanaugh MP, et al. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 1997; 94:4155-60.

• Background Reference 02:

  Lee A, Anderson AR, Stevens M, et al. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Eur. J. Histochem. 2013; 57:e11.

• Background Reference 03:

  Schneider N, Cordeiro S, Machtens JP, et al. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 2014; 289:1815-24.

• Background Reference 04:

  Boehmer C, Rajamanickam J, Schniepp R, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem. Biophys. Res. Commun. 2005; 329:738-42.

• Other Product Names:

  Solute carrier family 1 (glutamate transporter) member 7, AAAT, excitatory amino acid transporter 5, EAAT5

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  567316146

• Physical Properties:

  Liquid