Products for Research Use Only
RegisterLogin

PJA1 Antibody

CAT: 0223-8069-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-8069-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Ubiquitinization is an important cellular degradation process requiring sequential reactions that are mediated by three enzymes: E1, E2 and E3. PJA1, also known as Praja1 and RING finger protein 70, is a 643 amino acid E2-dependent E3-ubiquitin ligase that is abundantly expressed in the brain (1,2) . Through interaction and activation with the E2-ubiquitin ligase UBC4, PJA1 mediates substrate-specific ubiquitination via its RING finger domain and facilitates ubiquitination (3) . Overexpression of PJA1 in gastrointestinal cancers suggests that it may be responsible for the degradation of some anti-oncogenic proteins (4,5) .
NCBI Gene ID
64219
Swiss Prot
Q8NG27
Accession Number
NP_660095
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Homeostasis
Purification
PJA1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
PJA1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PJA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PJA1 antibody is human, mouse and rat reactive. At least two isoforms of PJA1 are known to exist; this antibody will detect both isoforms.
Symbol
PJA1
NCBI Official Name
Praja ring finger 1, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Yu P, Chen Y, Tagle DA, et al. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Genomics 2002; 79:869-74.
Background Reference 02
Zoabi M, Sadeh R, de Bie P, et al. PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Biochem. Biophys. Res. Commun. 2011; 408:393-8.
Background Reference 03
Doyle JM, Gao J, Wang J, et al. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol. Cell 2010; 39:963-74.
Background Reference 04
Saha T, Vardhini D, Tang Y, et al. RING finger-dependent ubiquitination by PRAJA is dependent on TGF-beta and potentially defines the functional status of the tumor suppressor ELF. Oncogene 2006; 25:693-705.
Other Product Names
Praja ring finger 1, E3 ubiquitin-protein ligase Praja-1, PRAJA1, RING finger protein 70, RNF70
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
41281725
Physical Properties
Liquid

Related Products

CatalogName
43-019PPJA1 Peptide
8069PPJA1 Peptide
22-227PJA2 Antibody
59-035PJA2 Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody

Alternative Products

CatalogName
70R-19311PJA1 antibody
A11179Anti-PJA1 Antibody
MBS8530020-01PJA1 Polyclonal Antibody
APR06900GPolyclonal PJA1 Antibody
526996-01PJA1

Popular Products