LIMA1 Antibody

CAT: 0223-8053-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-8053-01Size:0.02 mg
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Background
The Lim domain and actin-binding protein 1 (LIMA1) is cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles and is downregulated in some cancer cell lines (1,2) . LIMA1 is also a key molecule linking the cadherin-catenin complex to the actin cytoskeleton (3) . Recent studies have shown that EGF activates ERK1/2-dependent phosphorylation, ubiquitination and degradation of LIMA1, leading to increased invasiveness and metastasis of metastatic prostate cancer models (4) .
NCBI Gene ID
51474
Swiss Prot
Q9UHB6
Accession Number
NP_001107018
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Homeostasis
Purification
LIMA1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1320 - Human Colon Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (89%), Pig: (72%)
Buffer
LIMA1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LIMA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
LIMA1 antibody is human specific. At least four isoforms of LIMA1 are known to exist; this antibody will only detect the three largest isoforms.
Symbol
LIMA1
NCBI Official Name
LIM domain and actin binding 1
NCBI Organism
Homo sapiens
Background Reference 01
Maul RS and Chang DD. EPLIN, epithelial protein lost in neoplasm. Oncogene 1999; 18:7838-41.
Background Reference 02
Maul RS, Song Y, Amann KJ, et al. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. J. Cell Biol. 2003; 160:399-407.
Background Reference 03
Abe K and Takeichi M. EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc. Natl. Acad. Sci. USA 2008; 105:13-9.
Background Reference 04
Zhang S, Wang X, Iqval S, et al. Epidermal growth factor promotes protein degradation of epithelial protein lost in neoplasm (EPLIN), a putative metastasis suppressor, during epithelial-mesenchymal transition. J. Biol. Chem. 2013; 288:1469-79.
Other Product Names
LIM domain and actin-binding protein 1, PP624, EPLIN, SREBP3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
165905589
Physical Properties
Liquid

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