GJB2 Antibody

• Background:

  The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1) . Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2) . Other mutations in this gene have also been linked to a wide array of skin diseases (3) .

• NCBI Gene ID:

  2706

• Swiss Prot:

  P29033

• Accession Number:

  NP_003995

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  GJB2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1320 - Human Colon Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (94%), Sheep: (88%), Bovine: (88%), Chicken: (82%)

• Buffer:

  GJB2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GJB2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  GJB2 antibody is human specific.

• Symbol:

  GJB2

• NCBI Official Name:

  Gap junction protein, beta 2, 26kDa

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions – An update. FEBS Lett. 2014; 588:1186-92.

• Background Reference 02:

  Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.

• Background Reference 03:

  Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.

• Other Product Names:

  Gap junction beta-2 protein, connexin 26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, HID, KID, NSRD1, PPK

• Tested Applications:

  ELISA, WB

• Protein ID:

  42558283

• Physical Properties:

  Liquid